abstract：:Music is ubiquitous. Yet, its biological relevance is still an ongoing debate. Supporting the view that music had an ancestral role in courtship displays, a pilot study presented here provides preliminary evidence on the link between music and sexual selection. The underlying hypothesis is based on the fact that the s...

journal_title：Medical hypotheses

authors： Miani A

更新日期：2016-08-01 00:00:00

abstract：:Rushton bodies (RBs) are one of the characteristic features seen in the epithelial lining of odontogenic cysts mainly radicular, dentigerous and odontogenic keratocyst. It has two different histo-morphological appearances; granular and homogeneous. Although widely investigated, the exact pathogenesis and histogenesis ...

journal_title：Medical hypotheses

authors： Sarode GS,Sarode SC,Tupkari JV,Deshmukh R,Patil S

更新日期：2016-08-01 00:00:00

abstract：:Bone grafting uses a wide range of materials derived mainly from exogenous sources. Autogenous teeth are often used fresh or fixed with alcohol for later use. Proposed here is a method of using cryogenically preserved autogenous extracted teeth, which could be macerated after thawing. This method avoids the possibilit...

journal_title：Medical hypotheses

authors： Touyz LZ,Afrashtehfar KI

更新日期：2016-07-01 00:00:00

abstract：:Obesity is a major risk-factor for the development of insulin resistance, type 2 diabetes, and cardiovascular disease. Circulating molecules associated with obesity, such as saturated fatty acids and cholesterol crystals, stimulate the innate immune system to incite a chronic inflammatory state. Studies in mouse model...

journal_title：Medical hypotheses

authors： Demidowich AP,Davis AI,Dedhia N,Yanovski JA

更新日期：2016-07-01 00:00:00

abstract：:Epoxides as reactive intermediates of estrogen metabolism have been considered to be potential precursors of the 2- and 4-hydroxy, catechol estrogens and even to be mutagenic/carcinogenic agents themselves. The labile nature of the intermediates has made proof of their existence difficult in natural biological conditi...

journal_title：Medical hypotheses

authors： Raeside JI

更新日期：2016-06-01 00:00:00

abstract：:Ultrasound (US) is gaining recognition as a useful tool for assessing lung physiology and pathology. Yet, currently the skill of performing lung US is taught by experienced operators to novice ones, mainly by recognizing expected patterns. Recognizing the latter may be difficult and subjective. In this hypothesis we p...

journal_title：Medical hypotheses

authors： Dori G,Jakobson DJ

更新日期：2016-06-01 00:00:00

abstract：:Interventions focusing on the prevention and treatment of chronic non-communicable diseases are on rise. In the current article, we propose that dysfunction of the mesocortico-limbic reward system contributes to the emergence of the WHO-identified risk behaviors (tobacco use, unhealthy diet, physical inactivity and ha...

journal_title：Medical hypotheses

authors： Zsuga J,Tajti G,Papp C,Juhasz B,Gesztelyi R

更新日期：2016-05-01 00:00:00

abstract：:Multidrug resistance (MDR) is a phenomenon expressed by many tumors affecting the chemotherapy efficacy, treatment decision, and the disease prognosis. Considering its great implication, non-invasive approaches are needed to identify this phenomenon in early stages of the disease. This article discusses the potential ...

journal_title：Medical hypotheses

authors： Elkadi OA,Abdelbasset M

更新日期：2016-04-01 00:00:00

abstract：:Salt is a major mineral element that plays fundamental roles in health and disease. Excessive salt intake is a major cause of hypertension, cardiovascular disease and stroke. Miscarriage and preeclampsia are the most common pregnancy complications with multiple etiological factors, including inflammatory and autoimmun...

journal_title：Medical hypotheses

authors： Abdoli A

更新日期：2016-04-01 00:00:00

abstract：:Parathyroid hormone (PTH) acts as a controller of bone remodeling and has influence on periodontal tissues. In addition to the well-established catabolic effects (activation of bone resorption) of PTH, it is recognized that the PTH intermittent administration has anabolic effects (promotion of bone formation). However...

journal_title：Medical hypotheses

authors： Vasconcelos DF,Vasconcelos AC

更新日期：2016-03-01 00:00:00

abstract：:Vitamin A is a fat-soluble vitamin required for many physiological functions. The intracellular transport of vitamin A is assisted by proteins called cellular retinol-binding proteins (CRBP I/II). The absorption, storage and usage of vitamin A are regulated by a protein called lecithin:retinol acyltransferase (LRAT), ...

journal_title：Medical hypotheses

authors： Mezaki Y,Fujimi TJ,Senoo H,Matsuura T

更新日期：2016-03-01 00:00:00

abstract：:Accurate detection and prevention of overuse musculoskeletal injuries is limited by the nature of somatic tissue injury. In the pathogenesis of overuse injuries, it is well recognized that an abnormal inflammatory response occurs within somatic tissue before pain is perceived which can disrupt the normal remodeling pr...

journal_title：Medical hypotheses

authors： Gisselman AS,Baxter GD,Wright A,Hegedus E,Tumilty S

更新日期：2016-02-01 00:00:00

abstract：:Hypertensive left ventricular hypertrophy (LVH) is a maladaptive response to chronic pressure overload and a strong independent risk factor for cardiovascular disease. Regression of LVH is associated with improved prognosis. Regression of LVH with antihypertensive therapy (angiotensin-converting enzyme inhibitors, ang...

journal_title：Medical hypotheses

authors： Quintana-Villamandos B,Delgado-Baeza E

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common cardiac arrhythmia. Many studies have investigated the cause for the development of AF, however, the question remains unanswered. METHODS:A comparison of hydrodynamics between AF and sinus rhythm was performed. RESULTS:I proposed the hypothesis that atrial fibril...

journal_title：Medical hypotheses

authors： Tilman V

更新日期：2016-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common primary tumor of liver and its incidence continues to increase worldwide. HCC is a disease with multifactorial causes and genetic variability has been discussed as a risk factor for its development. Liver is a hormone-sensitive organ and therefore is influenced by gona...

journal_title：Medical hypotheses

authors： Baldissera VD,Alves AF,Almeida S,Porawski M,Giovenardi M

更新日期：2016-01-01 00:00:00

abstract：:Thyrotoxic periodic paralysis (TPP) frequently occurs on male individuals at their third and forth decades. The major site of involvement is the proximal muscles of lower limbs. Increasing evidence has shown that the occurrence of TPP is determined by multiple factors. We hypothesized that apart from hormonal fluctuat...

journal_title：Medical hypotheses

authors： Tang ZW,He Y,Yao Y,Qiu L,Tian HM

更新日期：2015-12-01 00:00:00

abstract：:It is hypothesized that a topical application of a sulfonylurea drug, which can inhibit the ATP-sensitive potassium-gated channels (Kir6.X/SUR) present in human hair bulb tissues, will inhibit hair growth in a targeted manner. Diazoxide is used to treat severe hypoglycemia due to hyperinsulinism of infancy. However, t...

journal_title：Medical hypotheses

authors： Newfield RS

更新日期：2015-12-01 00:00:00

abstract：:Contrast-induced nephropathy (CIN) is regarded as acute tubular necrosis resulting from the cytotoxicity of contrast media and the medullary hypoxia linking to the interplay of vasoconstriction and vasodilatation. Saline infusion may prevent CIN by inhibiting renin release and thus production of angiotensin II (ANG II...

journal_title：Medical hypotheses

authors： Wong PC,Guo J,Zhang A

更新日期：2015-12-01 00:00:00

abstract：:This article reviews the biochemical and physiological observations underpinning the synergism between ghrelin and ghrelin agonists with exercise, especially progressive resistance training that has been shown to increase muscle mass. The synergy of ghrelin agonists and physical exercise could be beneficial in conditi...

journal_title：Medical hypotheses

authors： Fuoco D,Kilgour RD,Vigano A

更新日期：2015-12-01 00:00:00

abstract：UNLABELLED:CRPS is an acute pain disease expressed as chronic pain with a severe loss of tissue and function. CRPS usually occurs after minor injuries and then progresses in a way that is scarcely controllable, or completely uncontrollable. This article addresses the functional control mechanism of a biological organis...

journal_title：Medical hypotheses

authors： van der Veen P

更新日期：2015-11-01 00:00:00

abstract：:Hypnosis and music interventions (HMIs) have shown positive influence on cancers for nearly 200years, but the underlying mechanisms were rarely explored systematically. The hypothesis suggests a potential curative efficacy of HMIs on cancers by inhibiting hypoxia inducible factor-1 (HIF-1), which is a key mediator of ...

journal_title：Medical hypotheses

authors： Wang JZ,Li L,Pan LL,Chen JH

更新日期：2015-11-01 00:00:00

abstract：:Exercise induced bronchospasm (EIB) affects approximately 10% of normal individuals with higher prevalence rates among children, obese adults, and competitive athletes. Although hyperpnea with dry air is the best known cause, the problem is multifactorial with atopy, asthma and chlorine all playing established roles. ...

journal_title：Medical hypotheses

authors： Simkin PA,Snitily BK

更新日期：2015-11-01 00:00:00

abstract：:Mucous membrane pemphigoid (MMP) is a subtype of autoimmune subepidermal blistering diseases characterized by autoantibodies to structural components of the hemidesmosome primarily affecting mucous membranes. Inflammation-related progressive scarring can lead to serious complications, including blindness, and the dise...

journal_title：Medical hypotheses

authors： Kasperkiewicz M,Płatkowska A,Zalewska A,Zillikens D

更新日期：2015-10-01 00:00:00

abstract：:Puberty is starting earlier than ever before and there are serious physiological and sociological implications as a result of this development. Current research has focused on the potential role of high caloric, and commensurate high adiposity, contributions to early puberty. However, girls with normal BMI also appear...

journal_title：Medical hypotheses

authors： Pitynski D,Flynn FW,Skinner DC

更新日期：2015-10-01 00:00:00

abstract：:The authors sought to establish whether maternal dietary methanol during pregnancy was a factor in the etiology of autism spectrum disorders. A seven item questionnaire was given to women who had given birth to at least one child after 1984. The subjects were solicited from a large primary care practice and several in...

journal_title：Medical hypotheses

authors： Walton RG,Monte WC

更新日期：2015-10-01 00:00:00

abstract：:In humans, the nasal retina projects to the contralateral hemisphere, whereas the temporal retina projects ipsilaterally. The nasotemporal line that divides the retina into crossed and uncrossed parts coincides with the vertical meridian through the fovea. This normal projection of the retina is severely altered in al...

journal_title：Medical hypotheses

authors： Banihani SM

更新日期：2015-10-01 00:00:00

abstract：:Mood expressions encompassing positive scales like "activity, elation, contemplation, calmness" and negative scales like "anger, excitement, depression, fatigue" were applied for introducing a new tool to assess the effects of acupuncture on brain structures. Traditional acupuncture points defined in the literature fo...

journal_title：Medical hypotheses

authors： Acker H,Schmidt-Rathjens C,Acker T,Fandrey J,Ehleben W

更新日期：2015-09-01 00:00:00

abstract：:Irritable Bowel Syndrome (IBS) is a condition that may be marked by abdominal pain, bloating, fullness, indigestion, belching, constipation and/or diarrhea. IBS symptoms can result from malabsorption of fructose. Fructose is a monosaccharide found naturally in small quantities in fruits and some vegetables, and in muc...

journal_title：Medical hypotheses

authors： DiNicolantonio JJ,Lucan SC

更新日期：2015-09-01 00:00:00

abstract：:Mild traumatic brain injury, often referred to as concussion, is a common, potentially debilitating, and costly condition. One of the main challenges in diagnosing and managing concussion is that there is not currently an objective test to determine the presence of a concussion and to guide return-to-play decisions fo...

journal_title：Medical hypotheses

authors： Cartwright MS,Dupuis JE,Bargoil JM,Foster DC

更新日期：2015-09-01 00:00:00

abstract：:Ebola virus (EBOV) infection is associated with modulation of cytokine expression in infected patients. EBOV has been shown to interact directly with immune cells (at minimum with macrophages and dendritic cells) and modulation of cytokine expression has also been observed in vitro, which is similar to that in vivo. T...

journal_title：Medical hypotheses

authors： Denner J

更新日期：2015-09-01 00:00:00

abstract：:Dietary chromium supplementation for the treatment of diabetes remains controversial. The prevailing view that chromium supplementation for glucose regulation is unjustified has been based upon prior studies showing mixed, modest-sized effects in patients with type 2 diabetes (T2DM). Based on chromium's potential to i...

journal_title：Medical hypotheses

authors： Brownley KA,Boettiger CA,Young L,Cefalu WT

更新日期：2015-07-01 00:00:00

abstract：:To discuss the possible pathogenesis of outlet obstructive constipation (OOC) and identify the theoretical basis of the Procedure for Prolapse and Hemorrhoids (PPH) used to treat outlet obstructive constipation (OOC). 19 patients diagnosed with outlet obstructive constipation (OOC) form the case group, and 9 healthy v...

journal_title：Medical hypotheses

authors： Qin Z,Pang L,Dai W,Yan W,Zhang J,Zhao Y,Li Q,Wu K,Zhou B

更新日期：2015-07-01 00:00:00

abstract：:The number of patients with diabetes has been expected around 300 million by 2025 and 366 million by 2030 by WHO. On the other hand, diabetic wounds as one of the common complications of diabetes represent major health challenges. Recently, wound care biological products have been proposed for treatment of chronic wou...

journal_title：Medical hypotheses

authors： Larijani B,Ghahari A,Warnock GL,Aghayan HR,Goodarzi P,Falahzadeh K,Arjmand B

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Operative risk prediction systems (logistic EuroSCORE I, EuroSCORE II and STS Score) are employed together with multidisciplinary discussion to contraindicate conventional surgery in patients with valvular heart disease and propose the employment of alternative transcatheter procedures. The EuroSCORE I has b...

journal_title：Medical hypotheses

authors： Anselmi A,Ruggieri VG,Harmouche M,Mascle S,Auffret V,Le Breton H,Beneux X,Verhoye JP

更新日期：2015-05-01 00:00:00

abstract：:Our hypothesis was that testosterone therapy (TT) interacts with previously undiagnosed thrombophilia-hypofibrinolysis, leading to hospitalization for deep venous thrombosis (DVT)-pulmonary emboli (PE). We determined the prevalence of DVT-PE associated with TT 147 men hospitalized in the last 12 months for DVT-PE. Of ...

journal_title：Medical hypotheses

authors： Glueck CJ,Friedman J,Hafeez A,Hassan A,Wang P

更新日期：2015-04-01 00:00:00

abstract：:Alzheimer's disease is a debilitating age-related disorder characterized by distinct pathological hallmarks, such as progressive memory loss and cognitive impairment. During the last few years, several cellular signaling pathways have been associated with the pathogenesis of Alzheimer's disease, such as Notch, mTOR an...

journal_title：Medical hypotheses

authors： Bastías-Candia S,Braidy N,Zolezzi JM,Inestrosa NC

更新日期：2015-04-01 00:00:00

abstract：:Based on a logic of balance mechanisms influencing information processing in tripartite synapses are proposed. It is hypothesized that the number of expressed astrocytic receptors determines balanced and imbalanced synaptic states. Synaptic information processing in mental disorders is underbalanced in depression, ove...

journal_title：Medical hypotheses

authors： Mitterauer BJ

更新日期：2015-04-01 00:00:00

abstract：:It is known, that initial events in atherosclerosis arise in the intima with a parallel influx of inflammatory cells. I propose the opposite - that the disease onset begins from the media vascular smooth muscle cell (VSMC) involvement and through its utilization of modified low-density lipoproteins (LDL), and free or ...

journal_title：Medical hypotheses

authors： Chepelenko GV

更新日期：2015-02-01 00:00:00

abstract：:Chronic stresses can induce physiological and psychological changes and result in stress-related neuropsychiatry, sometimes they may also contribute to hypersensitivity to pain known as stress-induced hyperalgesia (SIH). Recently it was found that GABAergic disinhibition is closely related to morphine and chronic infl...

journal_title：Medical hypotheses

authors： Dai S,Ma Z

更新日期：2014-12-01 00:00:00

abstract：:Alzheimer's disease (AD) a neurodegenerative disorder of widely distributed cortical networks evolves over years while A beta (Aβ) oligomer neurotoxicity occurs within seconds to minutes. This disparity combined with disappointing outcomes of anti-amyloid clinical trials challenges the centrality of Aβ as principal me...

journal_title：Medical hypotheses

authors： Engel PA

更新日期：2014-12-01 00:00:00